Regulation of gene expression in trypanosomatids: living with polycistronic transcription
C Clayton - Open biology, 2019 - royalsocietypublishing.org
In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …
[HTML][HTML] Emergence and adaptation of the cellular machinery directing antigenic variation in the African trypanosome
Survival of the African trypanosome within its mammalian hosts, and hence transmission
between hosts, relies upon antigenic variation, where stochastic changes in the composition …
between hosts, relies upon antigenic variation, where stochastic changes in the composition …
The mitochondrial R-loop
IJ Holt - Nucleic acids research, 2019 - academic.oup.com
The DNA in mitochondria contributes essential components of the organelle's energy
producing machinery that is essential for life. In 1971, many mitochondrial DNA molecules …
producing machinery that is essential for life. In 1971, many mitochondrial DNA molecules …
R-loop-dependent replication and genomic instability in bacteria
M Drolet, J Brochu - DNA repair, 2019 - Elsevier
DNA replication, the faithful copying of genetic material, must be tightly regulated to produce
daughter cells with intact copies of the chromosome (s). This regulated replication is initiated …
daughter cells with intact copies of the chromosome (s). This regulated replication is initiated …
RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei
MJ Girasol, M Krasilnikova… - Proceedings of the …, 2023 - National Acad Sciences
RNA–DNA hybrids are epigenetic features of all genomes that intersect with many
processes, including transcription, telomere homeostasis, and centromere function …
processes, including transcription, telomere homeostasis, and centromere function …
Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion
Switching of the Variant Surface Glycoprotein (VSG) in Trypanosoma brucei provides a
crucial host immune evasion strategy that is catalysed both by transcription and …
crucial host immune evasion strategy that is catalysed both by transcription and …
Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic …
Ribonucleotides represent a threat to DNA genome stability and transmission. Two types of
Ribonuclease H (RNase H) excise ribonucleotides when they form part of the DNA strand, or …
Ribonuclease H (RNase H) excise ribonucleotides when they form part of the DNA strand, or …
Telomere and subtelomere R-loops and antigenic variation in trypanosomes
Trypanosoma brucei is a kinetoplastid parasite that causes African trypanosomiasis, which
is fatal if left untreated. T. brucei regularly switches its major surface antigen, VSG, to evade …
is fatal if left untreated. T. brucei regularly switches its major surface antigen, VSG, to evade …
Bromodomain factor 5 is an essential regulator of transcription in Leishmania
NG Jones, V Geoghegan, G Moore… - Nature …, 2022 - nature.com
Leishmania are unicellular parasites that cause human and animal diseases. Like other
kinetoplastids, they possess large transcriptional start regions (TSRs) which are defined by …
kinetoplastids, they possess large transcriptional start regions (TSRs) which are defined by …
Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication
Homologous recombination (HR) has an intimate relationship with genome replication, both
during repair of DNA lesions that might prevent DNA synthesis and in tackling stalls to the …
during repair of DNA lesions that might prevent DNA synthesis and in tackling stalls to the …