Scientific review of the proarrhythmic risks of oligonucleotide therapeutics: are dedicated ICH S7B/E14 studies needed for low‐risk modalities?

Y Qu, KA Henderson, TA Harper Jr… - Clinical Pharmacology …, 2024 - Wiley Online Library
Oligonucleotide therapeutics (ONTs) represent a new modality with unique pharmacological
and chemical properties that modulate gene expression with a high degree of target …

Rheumatoid Arthritis Has Won the Battle but Not the War: How Many Joints Will We Save Tomorrow?

VV Oberemok, O Andreeva, K Laikova, E Alieva… - Medicina, 2023 - mdpi.com
Rheumatoid arthritis refers to joint diseases of unclear etiology whose final stages can lead
to unbearable pain and complete immobility of the affected joints. As one of the most widely …

Nucleic Acid Probes in Bio-Imaging and Diagnostics: Recent Advances in ODN-Based Fluorescent and Surface-Enhanced Raman Scattering Nanoparticle and …

MC Sardaru, NL Marangoci, R Palumbo, GN Roviello… - Molecules, 2023 - mdpi.com
Raman nanoparticle probes are a potent class of optical labels for the interrogation of
pathological and physiological processes in cells, bioassays, and tissues. Herein, we review …

Potent and durable gene modulation in heart and muscle with chemically defined siRNAs

HH Fakih, C Lochmann, R Gagnon, A Summers… - bioRxiv, 2024 - biorxiv.org
Small interfering RNA (siRNAs) hold immense promise for treating cardiac and muscular
diseases, but robust and scalable delivery to these tissues remains a challenge. Recent …

[PDF][PDF] AGE-RELATED CHANGES IN BONE DENSITY, MUSCLE MASS, AND JOINT INTEGRITY, AND THEIR IMPLICATIONS FOR THE DEVELOPMENT OF AGE …

S Majeed, S Mumtaz, M Aslam, H Kousar, M Asif… - researchgate.net
Background: Aging is related with the multitude of physiological changes, with alterations in
bone density, muscle mass, and joint integrity. These age-related changes are of significant …