[HTML][HTML] Retinal stem cell transplantation: Balancing safety and potential

MS Singh, SS Park, TA Albini, MV Canto-Soler… - Progress in retinal and …, 2020 - Elsevier
Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

Biomaterials for cell transplantation

N Mitrousis, A Fokina, MS Shoichet - Nature Reviews Materials, 2018 - nature.com
Cell transplantation holds immense potential for reversing diseases that are currently
incurable and for regenerating tissues. However, poor cell survival, cell aggregation and …

Gelatin-based materials in ocular tissue engineering

JB Rose, S Pacelli, AJ El Haj, HS Dua, A Hopkinson… - Materials, 2014 - mdpi.com
Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue
engineering on account of its excellent biocompatibility, ease of processing and availability …

Regenerative therapies for central nervous system diseases: a biomaterials approach

RY Tam, T Fuehrmann, N Mitrousis… - …, 2014 - nature.com
The central nervous system (CNS) has a limited capacity to spontaneously regenerate
following traumatic injury or disease, requiring innovative strategies to promote tissue and …

Hydrogels in ophthalmic applications

S Kirchhof, AM Goepferich, FP Brandl - European Journal of Pharmaceutics …, 2015 - Elsevier
More and more people worldwide are affected by severe eye diseases eventually leading to
visual impairment or blindness. In most cases, the treatment involves the application of …

Structural and molecular changes in the aging choroid: implications for age-related macular degeneration

KR Chirco, EH Sohn, EM Stone, BA Tucker, RF Mullins - Eye, 2017 - nature.com
Age-related macular degeneration (AMD) is a devastating disease-causing vision loss in
millions of people around the world. In advanced stages of disease, death of photoreceptor …

Stem cell based therapies for age-related macular degeneration: the promises and the challenges

H Nazari, L Zhang, D Zhu, GJ Chader… - Progress in retinal and …, 2015 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice

BA Tucker, IH Park, SD Qi, HJ Klassen, C Jiang, J Yao… - PloS one, 2011 - journals.plos.org
This study was designed to determine whether adult mouse induced pluripotent stem cells
(iPSCs), could be used to produce retinal precursors and subsequently photoreceptor cells …

Injectable hydrogels for central nervous system therapy

MM Pakulska, BG Ballios, MS Shoichet - Biomedical materials, 2012 - iopscience.iop.org
Diseases and injuries of the central nervous system (CNS) including those in the brain,
spinal cord and retina are devastating because the CNS has limited intrinsic regenerative …

Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery

SM Willerth, SE Sakiyama-Elbert - StemJournal, 2019 - content.iospress.com
Combining stem cells with biomaterial scaffolds serves as a promising strategy for
engineering tissues for both in vitro and in vivo applications. This updated review details …