Challenges and successes in developing new therapies for hepatitis C

R De Francesco, G Migliaccio - Nature, 2005 - nature.com
Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to
come because of the chronic nature of the infection, its high prevalence and the significant …

Novel insights into hepatitis C virus replication and persistence

R Bartenschlager, M Frese… - Advances in virus …, 2004 - books.google.com
C. Proteolytic Processing of Structural Proteins D. Proteolytic Processing of Nonstructural
Proteins E. Cis-Acting RNA Sequences Required for Replication F. Mechanism of RNA …

Inhibition of influenza virus production in virus-infected mice by RNA interference

Q Ge, L Filip, A Bai, T Nguyen… - Proceedings of the …, 2004 - National Acad Sciences
Influenza A virus infection is a major source of morbidity and mortality worldwide. Because
the effectiveness of existing vaccines and antiviral drugs is limited, development of new …

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

T Yokota, K Sugawara, K Ito, R Takahashi… - Biochemical and …, 2003 - Elsevier
Mutations in DJ-1 gene have been linked to autosomal recessive early onset parkinsonism
(AR-EOP). Although the mechanism of neuronal cell death due to DJ-1 mutation has not …

siRNA relieves chronic neuropathic pain

G Dorn, S Patel, G Wotherspoon… - Nucleic acids …, 2004 - academic.oup.com
Double stranded, short interfering RNAs (siRNA) of 21–22 nt length initiate a sequence‐
specific, post‐trancriptional gene silencing in animals and plants known as RNA …

siRNA therapeutics: big potential from small RNAs

RCC Ryther, AS Flynt, JA Phillips, JG Patton - Gene therapy, 2005 - nature.com
RNA interference (RNAi) is now an umbrella term referring to post-transcriptional gene
silencing mediated by either degradation or translation arrest of target RNA. This process is …

RNA interference against viruses: strike and counterstrike

J Haasnoot, EM Westerhout, B Berkhout - Nature biotechnology, 2007 - nature.com
RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that
is induced by double-stranded RNA. RNAi holds great promise as a novel nucleic acid …

[HTML][HTML] Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway

KJ Kim, KH Kim, HY Kim, HK Cho, N Sakamoto… - FEBS letters, 2010 - Elsevier
A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-
viral activity against the influenza virus, adenovirus, coxsackievirus, and the human …

Regulation of the hepatitis C virus genome replication by miR-199a

Y Murakami, HH Aly, A Tajima, I Inoue… - Journal of hepatology, 2009 - Elsevier
BACKGROUND/AIMS: Hepatitis C virus (HCV) infection causes chronic hepatitis and
hepatocellular carcinoma. Current anti-HCV therapies are based on interferon therapy …

Computational estimation and experimental verification of off-target silencing during posttranscriptional gene silencing in plants

P Xu, Y Zhang, L Kang, MJ Roossinck… - Plant …, 2006 - academic.oup.com
Successful application of posttranscriptional gene silencing (PTGS) for gene function study
in both plants and animals depends on high target specificity and silencing efficiency. By …