C. Proteolytic Processing of Structural Proteins D. Proteolytic Processing of Nonstructural Proteins E. Cis-Acting RNA Sequences Required for Replication F. Mechanism of RNA …
Q Ge, L Filip, A Bai, T Nguyen… - Proceedings of the …, 2004 - National Acad Sciences
Influenza A virus infection is a major source of morbidity and mortality worldwide. Because the effectiveness of existing vaccines and antiviral drugs is limited, development of new …
T Yokota, K Sugawara, K Ito, R Takahashi… - Biochemical and …, 2003 - Elsevier
Mutations in DJ-1 gene have been linked to autosomal recessive early onset parkinsonism (AR-EOP). Although the mechanism of neuronal cell death due to DJ-1 mutation has not …
G Dorn, S Patel, G Wotherspoon… - Nucleic acids …, 2004 - academic.oup.com
Double stranded, short interfering RNAs (siRNA) of 21–22 nt length initiate a sequence‐ specific, post‐trancriptional gene silencing in animals and plants known as RNA …
RCC Ryther, AS Flynt, JA Phillips, JG Patton - Gene therapy, 2005 - nature.com
RNA interference (RNAi) is now an umbrella term referring to post-transcriptional gene silencing mediated by either degradation or translation arrest of target RNA. This process is …
J Haasnoot, EM Westerhout, B Berkhout - Nature biotechnology, 2007 - nature.com
RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA. RNAi holds great promise as a novel nucleic acid …
KJ Kim, KH Kim, HY Kim, HK Cho, N Sakamoto… - FEBS letters, 2010 - Elsevier
A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti- viral activity against the influenza virus, adenovirus, coxsackievirus, and the human …
Y Murakami, HH Aly, A Tajima, I Inoue… - Journal of hepatology, 2009 - Elsevier
BACKGROUND/AIMS: Hepatitis C virus (HCV) infection causes chronic hepatitis and hepatocellular carcinoma. Current anti-HCV therapies are based on interferon therapy …
P Xu, Y Zhang, L Kang, MJ Roossinck… - Plant …, 2006 - academic.oup.com
Successful application of posttranscriptional gene silencing (PTGS) for gene function study in both plants and animals depends on high target specificity and silencing efficiency. By …