Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response

YY Wu, TK Sun, MS Chen, M Munir… - Frontiers in Cellular and …, 2023 - frontiersin.org
Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer
therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis …

Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

M Ashrafizadeh, MDA Paskeh, S Mirzaei… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

[HTML][HTML] Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas

A Zanotto-Filho, E Braganhol, K Klafke, F Figueiró… - Cancer letters, 2015 - Elsevier
Glioblastoma is a devastating primary brain tumor resistant to conventional therapies. In this
study, we tested the efficacy of combining temozolomide with curcumin, a phytochemical …

MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation

PK Bommareddy, S Aspromonte, A Zloza… - Science translational …, 2018 - science.org
Melanoma is an aggressive cutaneous malignancy, but advances over the past decade
have resulted in multiple new therapeutic options, including molecularly targeted therapy …

Chemotherapy and oncolytic virotherapy: advanced tactics in the war against cancer

A Nguyen, L Ho, Y Wan - Frontiers in oncology, 2014 - frontiersin.org
Cancer is a traitorous archenemy that threatens our survival. Its ability to evade detection
and adapt to various cancer therapies means that it is a moving target that becomes …

Virotherapy: From single agents to combinatorial treatments

AM Malfitano, S Di Somma, CA Iannuzzi… - Biochemical …, 2020 - Elsevier
Virotherpay is emerging as a promising strategy against cancer, and three oncolytic viruses
(OVs) have gained approval in different countries for the treatment of several cancer types …

[HTML][HTML] Crosstalk between oncolytic viruses and autophagy in cancer therapy

KT Jin, XH Tao, YB Fan, SB Wang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Oncolytic viruses have attracted attention as a promising strategy in cancer therapy owing to
their ability to selectively infect and kill tumor cells, without affecting healthy cells. They also …

The oncolytic virus dl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid …

C Passaro, F Borriello, V Vastolo, S Di Somma… - …, 2015 - pmc.ncbi.nlm.nih.gov
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human solid tumor and
current treatments are ineffective in increasing patients' survival. Thus, the development of …

Immunology meets bioengineering: Improving the effectiveness of glioblastoma immunotherapy

Z Fekrirad, A Barzegar Behrooz, S Ghaemi… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is the main malignant brain tumor in adults. It has a
poor survival rate and a short disease-free life in spite of all available treatments. The …

Inhibition of MEK-ERK pathway enhances oncolytic vaccinia virus replication in doxorubicin-resistant ovarian cancer

S Lee, W Yang, DK Kim, H Kim, M Shin, KU Choi… - Molecular Therapy …, 2022 - cell.com
Oncolytic vaccinia virus (OVV) has been reported to induce cell death in various types of
cancer; however, the oncolytic activity of OVV in drug-resistant ovarian cancer remains …