Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Glial cells as therapeutic approaches in brain ischemia-reperfusion injury

IH Hernández, M Villa-González, G Martín, M Soto… - Cells, 2021 - mdpi.com
Ischemic stroke is the second cause of mortality and the first cause of long-term disability
constituting a serious socioeconomic burden worldwide. Approved treatments include …

Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention

DF Silva, JE Selfridge, J Lu, E Lezi, SM Cardoso… - Advances in …, 2012 - Elsevier
Mitochondria from persons with Alzheimer's disease (AD) differ from those of age-matched
control subjects. Differences in mitochondrial morphology and function are well …

[HTML][HTML] Electroacupuncture inhibits apoptosis of peri-ischemic regions via modulating p38, extracellular signal-regulated kinase (ERK1/2), and c-Jun N terminal …

J Liu, Q Wang, S Yang, J Huang, X Feng… - … medical journal of …, 2018 - ncbi.nlm.nih.gov
Background Previous studies suggested that inhibition of apoptosis prevents the dysfunction
of ischemia-reperfusion injury. In the pathogenesis of ischemia-reperfusion injury …

The dose-response effect of acute intravenous transplantation of human umbilical cord blood cells on brain damage and spatial memory deficits in neonatal hypoxia …

S De Paula, S Greggio, DR Marinowic, DC Machado… - Neuroscience, 2012 - Elsevier
Despite the beneficial effects of cell-based therapies on brain repair shown in most studies,
there has not been a consensus regarding the optimal dose of human umbilical cord blood …

[HTML][HTML] The octapetide NAP alleviates intestinal and extra-intestinal anti-inflammatory sequelae of acute experimental colitis

MM Heimesaat, E Giladi, AA Kühl, S Bereswill, I Gozes - Peptides, 2018 - Elsevier
The octapeptide NAP has been shown to exert neuroprotective properties and reduce neuro-
inflammatory responses. The aim of the present study was to investigate if NAP provides anti …

[HTML][HTML] Perinatal hypoxic-ischemic damage: review of the current treatment possibilities

A Frajewicki, Z Laštůvka, V Borbelyova… - Physiological …, 2020 - ncbi.nlm.nih.gov
Neonatal hypoxic-ischemic encephalopathy is a disorder with heterogeneous manifestation
due to asphyxia during perinatal period. It affects approximately 3–12 children per 1000 live …

Phytoestrogen coumestrol attenuates brain mitochondrial dysfunction and long-term cognitive deficits following neonatal hypoxia–ischemia

JBR Anastacio, EF Sanches, F Nicola, F Odorcyk… - International Journal of …, 2019 - Elsevier
Abstract Introduction Neonatal Hypoxia-Ischemia (HI) is a major cause of morbidity and
mortality, and is frequently associated with short and long-term neurologic and cognitive …

Therapeutic advances for treating memory impairments in perinatal brain injuries with implications for cerebral palsy: a systematic review and meta-analysis of …

CMS da Silva Calado, R Manhães-de-Castro… - Experimental …, 2023 - Elsevier
Cerebral palsy (CP) is a neurodevelopmental disorder caused by damage to the immature
brain. CP is considered the main cause of physical disability in childhood. Studies have …

[HTML][HTML] Electroacupuncture ameliorates post-stroke learning and memory through minimizing ultrastructural brain damage and inhibiting the expression of MMP-2 …

R Lin, K Yu, X Li, J Tao, Y Lin… - Molecular …, 2016 - spandidos-publications.com
The aim of the present study was to investigate the potential neuroprotective effects of
electroacupuncture (EA) in the treatment of cerebral ischemia/reperfusion (I/R) injury, and to …