Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Sleep disturbances and depression are closely linked and share a bidirectional relationship.
These interconnections can inform the pathophysiology underlying each condition. Insomnia …

Background Subthreshold depression is highly prevalent in adolescence, but compared to
major depressive disorder, the clinical impact is under-researched. The aim of this review …

The bidirectional relationship between depression and chronic pain is well-recognized, but
their clinical management remains challenging. Here we characterize the shared risk factors …

Over the past decade, biomarker discovery has become a key goal in psychiatry to aid in the
more reliable diagnosis and prognosis of heterogeneous psychiatric conditions and the …

Despite significant improvements in our understanding of brain diseases, many barriers
remain. Cognitive neuroscience faces four major challenges: complex structure–function …

What changes in brain function cause the debilitating symptoms of depression? Can we use
the answers to this question to invent more effective, faster acting antidepressant drug …

Temporal neural synchrony disruption can be linked to a variety of symptoms of major
depressive disorder (MDD), including mood rigidity and the inability to break the cycle of …

Research in computational psychiatry is dominated by models of behavior. Subjective
experience during behavioral tasks is not well understood, even though it should be relevant …

Assessment of mental illness typically relies on a disorder classification system that is
considered to be at odds with the vast disorder comorbidity and symptom heterogeneity that …