One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid …
AM Wiedeman, SI Barr, TJ Green, Z Xu, SM Innis… - Nutrients, 2018 - mdpi.com
Choline, an essential dietary nutrient for humans, is required for the synthesis of the neurotransmitter, acetylcholine, the methyl group donor, betaine, and phospholipids; and …
Cardiovascular disease (CVD) is the leading cause of death in the United States. For years, dietary cholesterol was implicated in increasing blood cholesterol levels leading to the …
N Arias, S Arboleya, J Allison, A Kaliszewska… - Nutrients, 2020 - mdpi.com
Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which, upon absorption by the host …
Choline has been recognized as an essential nutrient by the Food and Nutrition Board of the National Academies of Medicine since 1998. Its metabolites have structural, metabolic, and …
M Xu, J Zheng, T Hou, H Lin, T Wang, S Wang… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE To investigate the causal role of choline metabolites mediating sodium–glucose cotransporter 2 (SGLT2) inhibition in coronary artery disease (CAD) and type 2 diabetes …
MM Berger, A Shenkin, A Schweinlin, K Amrein… - Clinical Nutrition, 2022 - Elsevier
Background Trace elements and vitamins, named together micronutrients (MNs), are essential for human metabolism. Recent research has shown the importance of MNs in …
R Velazquez, E Ferreira, S Knowles, C Fux… - Aging cell, 2019 - Wiley Online Library
Currently, there are no effective therapies to ameliorate the pathological progression of Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to …
H Demmelmair, B Koletzko - … Practice & Research Clinical Endocrinology & …, 2018 - Elsevier
Fat is the main energy providing component in human milk and comprising a complex mixture of different lipid species, with quantitative dominance of triglycerides. After …