CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands

J Korbecki, S Grochans, I Gutowska, K Barczak… - International journal of …, 2020 - mdpi.com
CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC
domain that play an important role in immune system cells, such as CD4+ and CD8+ …

Chemokines and chemokine receptors: new insights into cancer-related inflammation

G Lazennec, A Richmond - Trends in molecular medicine, 2010 - cell.com
Chemokines are involved in cellular interactions and tropism in situations frequently
associated with inflammation. Recently, the importance of chemokines and chemokine …

Senescent tumor cells lead the collective invasion in thyroid cancer

YH Kim, YW Choi, J Lee, EY Soh, JH Kim… - Nature …, 2017 - nature.com
Cellular senescence has been perceived as a barrier against carcinogenesis. However, the
senescence-associated secretory phenotype (SASP) of senescent cells can promote …

Interstitial flow influences direction of tumor cell migration through competing mechanisms

WJ Polacheck, JL Charest… - Proceedings of the …, 2011 - National Acad Sciences
Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This
creeping fluid flow has been shown to affect the morphology and migration of cells such as …

The metastasis-promoting roles of tumor-associated immune cells

HA Smith, Y Kang - Journal of molecular medicine, 2013 - Springer
Tumor metastasis is driven not only by the accumulation of intrinsic alterations in malignant
cells, but also by the interactions of cancer cells with various stromal cell components of the …

Metastasis review: from bench to bedside

AM Alizadeh, S Shiri, S Farsinejad - Tumor biology, 2014 - Springer
Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment

Y Dai, X Zhang, Y Ou, L Zou, D Zhang, Q Yang… - Cell Communication and …, 2023 - Springer
Breast cancer exhibits the highest global incidence among all tumor types. Regardless of
the type of breast cancer, metastasis is a crucial cause of poor prognosis. Anoikis, a form of …

The role of CCL21/CCR7 chemokine axis in breast cancer progression

B Rizeq, MI Malki - Cancers, 2020 - mdpi.com
Breast cancer is a leading cause of cancer-related deaths worldwide, predominantly caused
by metastasis. It is generally accepted that the pattern of breast cancer metastasis is largely …

Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells

M Thirunavukkarasan, C Wang, A Rao, T Hind, YR Teo… - PloS one, 2017 - journals.plos.org
Short chain fatty acids (2 to 6 carbons in length) are ubiquitous lipids that are present in
human plasma at micromolar concentrations. In addition to serving as metabolic precursors …

Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression …

J Whyte, O Bergin, A Bianchi, S McNally… - Breast Cancer Research, 2009 - Springer
Seven classes of mitogen-activated protein kinase (MAPK) intracellular signalling cascades
exist, four of which are implicated in breast disease and function in mammary epithelial cells …