Excessive hydrogen peroxide is harmful for almost all cell components, so its rapid and
efficient removal is of essential importance for aerobically living organisms. Conversely …

This review gives an overview about the structural organisation of different evolutionary lines
of all enzymes capable of efficient dismutation of hydrogen peroxide. Major potential …

Biological macromolecules are polymers and therefore the restraints for macromolecular
refinement can be subdivided into two sets: restraints that are applied to atoms that all …

Catalases continue to present a challenge and are an object of interest to the biochemist
despite more than 100 years of study. More than 120 sequences, seven crystal structures …

Cyclic peptide natural products represent an important class of bioactive compounds and
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …

The past 15 years have seen an explosive growth in the number of enzymatic reactions
found to proceed by mechanisms involving free radicals as intermediates. One of us learned …

The structure of the peroxisomal catalase A from the budding yeast Saccharomyces
cerevisiae, with 515 residues per subunit, has been determined and refined to 2.4 Å …

The review focuses on four issues that are critical for the understanding of monofunctional
catalases. How hydrogen peroxide (H2O2) reaches the active site and outcompetes water …

Most fungi have several monofunctional heme-catalases. Filamentous ascomycetes
(Pezizomycotina) have two types of large-size subunit catalases (L1 and L2). L2-type are …

The catalase-peroxidase encoded by katG of Burkholderia pseudomallei (BpKatG) is 65%
identical with KatG of Mycobacterium tuberculosis, the enzyme responsible for the activation …