Recent advances in anti-virulence therapeutic strategies with a focus on dismantling bacterial membrane microdomains, toxin neutralization, quorum-sensing …

O Fleitas Martínez, MH Cardoso, SM Ribeiro… - Frontiers in cellular …, 2019 - frontiersin.org
Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

Quorum sensing inhibitors as Therapeutics: Bacterial biofilm inhibition

A Vashistha, N Sharma, Y Nanaji, D Kumar, G Singh… - Bioorganic …, 2023 - Elsevier
The overuse and inappropriate use of antibiotics to treat bacterial infections has led to the
development of multiple drug resistant strains. Biofilm is a complex microorganism …

[HTML][HTML] Growing emergence of drug-resistant Pseudomonas aeruginosa and attenuation of its virulence using quorum sensing inhibitors: A critical review

S Bhardwaj, S Bhatia, S Singh… - Iranian journal of basic …, 2021 - ncbi.nlm.nih.gov
A perilous increase in the number of bacterial infections has led to developing throngs of
antibiotics for increasing the quality and expectancy of life. Pseudomonas aeruginosa is …

Widespread existence of quorum sensing inhibitors in marine bacteria: potential drugs to combat pathogens with novel strategies

J Zhao, X Li, X Hou, C Quan, M Chen - Marine drugs, 2019 - mdpi.com
Quorum sensing (QS) is a phenomenon of intercellular communication discovered mainly in
bacteria. A QS system consisting of QS signal molecules and regulatory protein components …

An autoinducer analogue reveals an alternative mode of ligand binding for the LasR quorum-sensing receptor

JE Paczkowski, AR McCready, JP Cong, Z Li… - ACS chemical …, 2019 - ACS Publications
Bacteria use a cell–cell communication process called quorum sensing to coordinate
collective behaviors. Quorum sensing relies on production and group-wide detection of …

Dihydropyrrolones as bacterial quorum sensing inhibitors

B Almohaywi, TT Yu, G Iskander, DSH Chan… - Bioorganic & Medicinal …, 2019 - Elsevier
Bacteria regulate their pathogenicity and biofilm formation through quorum sensing (QS),
which is an intercellular communication system mediated by the binding of signaling …

Functional diversity of quorum sensing receptors in pathogenic bacteria: Interspecies, intraspecies and interkingdom level

F Khan, A Javaid, YM Kim - Current drug targets, 2019 - ingentaconnect.com
The formation of biofilm by pathogenic bacteria is considered as one of the most powerful
mechanisms/modes of resistance against the action of several antibiotics. Biofilm is formed …

Trichoderma‐derived emodin competes with ExpR and ExpI of Pectobacterium carotovorum subsp. carotovorum to biocontrol bacterial soft rot

X Zhan, R Wang, M Zhang, Y Li, T Sun… - Pest Management …, 2024 - Wiley Online Library
BACKGROUND Quorum sensing inhibitors (QSIs) are an emerging control tool that inhibits
the quorum sensing (QS) system of pathogenic bacteria. We aimed to screen for potential …

Heterocyclic Chemistry Applied to the Design of N-Acyl Homoserine Lactone Analogues as Bacterial Quorum Sensing Signals Mimics

Q Zhang, S Li, M Hachicha, M Boukraa, L Soulère… - Molecules, 2021 - mdpi.com
N-acyl homoserine lactones (AHLs) are small signaling molecules used by many Gram-
negative bacteria for coordinating their behavior as a function of their population density …

Design and synthesis of aryl-substituted pyrrolidone derivatives as quorum sensing inhibitors

Z Liu, P Zhang, Y Qin, N Zhang, Y Teng, H Venter… - Bioorganic …, 2020 - Elsevier
Quorum sensing, a common cell-to-cell communication system, is considered to have
promising application in antibacterial therapy since they are expected to induce lower …