Small heat shock proteins (sHsps) are conserved across species and are important in stress
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …

Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which
Epstein-Barr virus (EBV) infection is a likely prerequisite. Due to the homology between …

Brain endothelial cells form a paracellular and transcellular barrier to many blood-borne
solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier …

Each year, 10 million people worldwide survive the neurologic injury associated with a
stroke. Importantly, stroke survivors have more than twice the risk of subsequently …

The brain is generally resistant to regeneration after damage. The cerebral endogenous
mechanisms triggering brain self-recovery have remained unclarified to date. We here …

Misfolding, aggregation, and aberrant accumulation of proteins are central components in
the progression of neurodegenerative disease. Cellular molecular chaperone systems …

Eighty percent of individuals with multiple sclerosis (MS) initially develop a clinical pattern
with periodic relapses followed by remissions, called relapsing-remitting MS (RRMS). This …

The heat-shock response, one of the main pro-survival mechanisms of a living organism,
has evolved as the biochemical response of cells to cope with heat stress. The most well …

Astrocytes limit inflammation after CNS injury, at least partially by physically containing it
within an astrocytic scar at the injury border. We report here that astrocytic transforming …