International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for …
F Bachelerie, A Ben-Baruch, AM Burkhardt… - Pharmacological …, 2014 - ASPET
Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
Mechanisms of regulation of the chemokine-receptor network
The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …
of leukocytes during normal immune function and as a key aspect of the inflammatory …
Predicting multiple conformations via sequence clustering and AlphaFold2
Abstract AlphaFold2 (ref.) has revolutionized structural biology by accurately predicting
single structures of proteins. However, a protein's biological function often depends on …
single structures of proteins. However, a protein's biological function often depends on …
AlphaFold2 fails to predict protein fold switching
D Chakravarty, LL Porter - Protein Science, 2022 - Wiley Online Library
AlphaFold2 has revolutionized protein structure prediction by leveraging sequence
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …
Protein dynamism and evolvability
N Tokuriki, DS Tawfik - Science, 2009 - science.org
The traditional view that proteins possess absolute functional specificity and a single, fixed
structure conflicts with their marked ability to adapt and evolve new functions and structures …
structure conflicts with their marked ability to adapt and evolve new functions and structures …
Is the cell really a machine?
DJ Nicholson - Journal of theoretical biology, 2019 - Elsevier
It has become customary to conceptualize the living cell as an intricate piece of machinery,
different to a man-made machine only in terms of its superior complexity. This familiar …
different to a man-made machine only in terms of its superior complexity. This familiar …
Prediction of multiple conformational states by combining sequence clustering with AlphaFold2
Abstract AlphaFold2 (AF2) has revolutionized structural biology by accurately predicting
single structures of proteins and protein-protein complexes. However, biological function is …
single structures of proteins and protein-protein complexes. However, biological function is …
[图书][B] Introduction to proteins: structure, function, and motion
Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
Biophysics of protein evolution and evolutionary protein biophysics
The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
Evolution of fold switching in a metamorphic protein
Metamorphic proteins switch between different folds, defying the protein folding paradigm. It
is unclear how fold switching arises during evolution. With ancestral reconstruction and …
is unclear how fold switching arises during evolution. With ancestral reconstruction and …