Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Stimulator of interferon genes (STING) is an essential adaptor protein required for the
inflammatory response to cytosolic DNA. dsDNA activates cGAS to generate cGAMP, which …

Obesity is characterized by an increase in body weight associated with an exaggerated
enlargement of the adipose tissue. Obesity has serious negative effects because it is …

The cGMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway plays a
critical role in sensing dsDNA localized to the cytosol, resulting in the activation of a robust …

Type 1 diabetes (T1D) is an autoimmune disease characterized by autoreactive T cell-
mediated destruction of insulin-producing pancreatic beta-cells. Loss of beta-cells leads to …

Peptidylarginine deiminases (PADs) are calcium-dependent enzymes that mediate
citrullination, an irreversible post-translational modification (PTM). PAD enzymes have …

Neutrophils were long considered to be a short-lived homogenous cell population, limited to
their role as first responders in anti-bacterial and-fungal immunity. While it is true that …

The generation of post-translational modifications (PTMs) in human proteins is a
physiological process leading to structural and immunologic variety in proteins, with …

Neutrophil extracellular traps (NETs) are complex structures released by activated
neutrophils during inflammatory responses. Due to their unique potential for causing tissue …