This paper presents the current state of knowledge on chloroquine disposition, with special
emphasis on stereoselectivity and microsomal metabolism. In addition, the impact of the …

Emerging resistance to chloroquine (CQ) by Plasmodium vivax threatens the health of the
hundreds of millions of people routinely exposed to the risk of infection with this organism …

Two soldiers continued weekly prophylaxis with 300 mg chloroquine base on their return to
Australia from Papua New Guinea but were not protected against Plasmodium vivax …

1. The pharmacokinetics of hydroxychloroquine were studied in five healthy volunteers
following an intravenous infusion of 155 mg (2.47+/‐0.25 mg kg‐1) racemic …

Since in vitro studies and a preliminary clinical report suggested the efficacy of chloroquine
for COVID-19-associated pneumonia, there is increasing interest in this old antimalarial …

For the past 300 years antimalarial dosage regimens have not been based on
pharmacokinetk information. However, now that this information is available, it is appropriate …

The prevention and management of malaria is primarily based on the use of drugs. Clinical
trials have however revealed that between individuals there is large variability in the …

Studies of the prevalence and incidence of malaria were conducted in children< 10 years
old living in 10 rural villages on the island of Espiritu Santo, Vanuatu, south-west Pacific …

The pharmacokinetics of the slow acting antirheumatic drugs (SAARDs),
hydroxychloroquine, chloroquine, penicillamine, the gold complexes and sulphasalazine, in …

Parasitic infections such as malaria, schistosomiasis, trypanosomiasis and onchoceriasis
are the scourge of the tropical countries. Many of the drugs used for the treatment of tropical …