The Wnt signaling pathway is known as one of the important molecular cascades that
regulate cell fate throughout lifespan. The Wnt signaling pathway is further separated into …

The development of suitable biomaterials with the ability to improve repair and regeneration
of human tissues is continuously in progress, and mechanical properties of biomaterials play …

Abstract Purpose of Review The bone is able to adapt its structure to mechanical signals via
the bone remodeling process governed by mechanosensitive osteocytes. With aging, an …

Organisms rely on mechanosensing mechanisms to adapt to changes in their mechanical
environment. Fluid-filled network structures not only ensure efficient transport but can also …

Skeletal fragility in the elderly does not simply result from a loss of bone mass. However, the
mechanisms underlying the concurrent decline in bone mass, quality, and …

Abstract Purpose of Review Postmenopausal osteoporosis reduces circulating estrogen
levels, which leads to osteoclast resorption, bone loss, and fracture. This review addresses …

In recent years, our scientific interest in spaceflight has grown exponentially and resulted in
a thriving area of research, with hundreds of astronauts spending months of their time in …

Bone is a remarkable tissue that can respond to external stimuli. The importance of
mechanical forces on the mass and structural development of bone has long been accepted …

In bone remodeling, maturation of the newly formed osteonal tissue is associated with a
rapid primary increase followed by a slower secondary increase of mineralization. This …

Osteocytes are considered to be the major mechanosensory cells of bone, but how
osteocytes in vivo process, perceive, and respond to mechanical loading remains poorly …