Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …

Eosinophils are a group of granulocytes well known for their capacity to protect the host from
parasites and regulate immune function. Diverse biological roles for eosinophils have been …

The defining pathology of tuberculosis is the granuloma, an organized structure derived from
host immune cells that surrounds infecting Mycobacterium tuberculosis. As the location of …

RNA viruses generate defective viral genomes (DVGs) that can interfere with replication of
the parental wild-type virus. To examine their therapeutic potential, we created a DVG by …

Eosinophils are bone marrow-derived granulocytes that are traditionally associated with
type 2 immune responses, such as those that occur during parasite infections and allergy …

Targeted therapy and immunotherapy have brought hopes for precision cancer treatment.
However, complex physiological barriers and tumor immunosuppression result in poor …

Granulocytes are innate immune effector cells with essential functions in host resistance to
bacterial infections. I will discuss emerging evidence that during Mycobacterium tuberculosis …

Mycobacterium tuberculosis (Mtb)-infected neutrophils are often found in the airways of
patients with active tuberculosis (TB), and excessive recruitment of neutrophils to the lung is …

Influx of eosinophils into the lungs is typically associated with type II responses during
allergy and fungal and parasitic infections. However, we previously reported that eosinophils …