The epigenome is dynamic and forged by epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA species …
J Xu, L Yu, J Guo, J Xiang, Z Zheng, D Gao… - Stem Cell Research & …, 2019 - Springer
Background Pigs have emerged as one of the most popular large animal models in biomedical research, which in many cases is considered as a superior choice over rodent …
RA Scarfone, SM Pena, KA Russell, DH Betts… - BMC veterinary …, 2020 - Springer
Induced pluripotent stem cells (iPSCs) are undifferentiated stem cells characterized by the ability to differentiate into any cell type in the body. iPSCs are a relatively new and rapidly …
Embryonic development is arguably the most complex process an organism undergoes during its lifetime, and understanding this complexity is best approached with a systems …
Y Bai, X Dai, Y Li, L Wang, W Li, Y Liu, Y Cheng… - Scientific reports, 2019 - nature.com
Long noncoding RNAs (lncRNAs) have been identified in many mammals and plants and are known to play crucial roles in multiple biological processes. Pineapple is an important …
Y Ling, Q Zheng, Y Li, M Sui, H Wu, Y Zhang… - Frontiers in …, 2019 - frontiersin.org
Pre-implantation development is a dynamic, complex and precisely regulated process that is critical for mammalian development. There is currently no description of the role of the long …
EK Skalon, NV Panyushev, OI Podgornaya… - Non-coding RNA, 2024 - mdpi.com
Background: Transposable elements (TEs) are major components of eukaryotic genomes. The extensive body of evidence suggests that although they were once considered …
X He, C Tan, Z Li, C Zhao, J Shi, R Zhou… - Biology …, 2019 - journals.biologists.com
Somatic cell nuclear transfer (SCNT) is the only method known to rapidly reprogram differentiated cells into totipotent embryos. Most cloned embryos become arrested before …
PZ Schall, KE Latham - American Journal of Physiology …, 2021 - journals.physiology.org
The morula-to-blastocyst transition (MBT) culminates with formation of inner cell mass (ICM) and trophectoderm (TE) lineages. Recent studies identified signaling pathways driving …