All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …

Although various methods have been tried to study and treat cancer, the cancer remains a
major challenge for human medicine today. One important reason for this is the presence of …

Slower epigenetic aging is associated with exposure to green space (greenness); however,
the longitudinal relationship has not been well studied, particularly in minority groups. We …

Abstract α-Klotho (klotho) is a protein involved in suppressing oxidative stress and
inflammation. In animal models, it is reported to underlie numerous aging phenotypes and …

Epigenetic clocks use DNA methylation to estimate biological age. Whether body
composition and physical activity are associated with these clocks is not well understood …

Background: Epigenetic clocks have been associated with cancer risk in several
observational studies. Nevertheless, it is unclear whether they play a causal role in cancer …

Background DNA methylation (DNAm) may play a role in age-related outcomes. It is not yet
known which DNAm-based biomarkers of age acceleration (BoAA) has the strongest …

Background: Hypertension is common in older individuals and is a major risk factor for
cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of …

Background Healthy eating is associated with lower risks of disease and mortality, but the
mechanisms underlying these associations are unclear. Age is strongly related to health …

Epigenetic age acceleration is considered a measure of biological aging based on genome-
wide patterns of DNA methylation. Although age acceleration has been associated with the …