Trained immunity—basic concepts and contributions to immunopathology

J Ochando, WJM Mulder, JC Madsen… - Nature Reviews …, 2023 - nature.com
Trained immunity is a functional state of the innate immune response and is characterized
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …

Factors that influence the immune response to vaccination

P Zimmermann, N Curtis - Clinical microbiology reviews, 2019 - Am Soc Microbiol
There is substantial variation between individuals in the immune response to vaccination. In
this review, we provide an overview of the plethora of studies that have investigated factors …

100 years of Mycobacterium bovis bacille Calmette-Guérin

C Lange, P Aaby, MA Behr, PR Donald… - The Lancet Infectious …, 2022 - thelancet.com
Summary Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …

Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

E Nemes, H Geldenhuys, V Rozot… - … England Journal of …, 2018 - Mass Medical Soc
Abstract Background Recent Mycobacterium tuberculosis infection confers a predisposition
to the development of tuberculosis disease, the leading killer among global infectious …

Immunology of Mycobacterium tuberculosis Infections

JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

100 years of Bacillus Calmette–Guérin immunotherapy: from cattle to COVID-19

N Lobo, NA Brooks, AR Zlotta, JD Cirillo… - Nature Reviews …, 2021 - nature.com
Abstract Bacillus Calmette–Guérin (BCG) is the most widely used vaccine worldwide and
has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour …

The global burden of tuberculosis mortality in children: a mathematical modelling study

PJ Dodd, CM Yuen, C Sismanidis… - The Lancet Global …, 2017 - thelancet.com
Background Tuberculosis in children is increasingly recognised as an important component
of the global tuberculosis burden, with an estimated 1 million cases in 2015. Although …

Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis

A Roy, M Eisenhut, RJ Harris, LC Rodrigues, S Sridhar… - Bmj, 2014 - bmj.com
Objectives To determine whether BCG vaccination protects against Mycobacterium
tuberculosis infection as assessed by interferon γ release assays (IGRA) in children. Design …

The status of tuberculosis vaccine development

LK Schrager, J Vekemens, N Drager… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis represents the leading global cause of death from an infectious agent.
Controlling the tuberculosis epidemic thus represents an urgent global public health priority …

Duration of BCG protection against tuberculosis and change in effectiveness with time since vaccination in Norway: a retrospective population-based cohort study

P Nguipdop-Djomo, E Heldal, LC Rodrigues… - The Lancet infectious …, 2016 - thelancet.com
Background Little is known about how long the BCG vaccine protects against tuberculosis.
We assessed the long-term vaccine effectiveness (VE) in Norwegian-born individuals …