Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

Covering: December 2005 to June 2016. Previous review: Nat. Prod. Rep., 2006, 23, 673–
698 Over the last decade, great efforts have been made to conduct phytochemistry research …

Background: Oxidative stress from elevated reactive oxygen species (ROS) has been
reported to induce cell apoptosis and may provide a means to target cancer cells. Celastrol …

Peroxiredoxins (PRDXs) are antioxidant enzymes, known to catalyze peroxide reduction to
balance cellular hydrogen peroxide (H 2 O 2) levels, which are essential for cell signaling …

Tumour cells often display an active metabolic profile, leading to the intracellular
accumulation of reactive oxygen species. As a member of the peroxidase family …

The peroxiredoxin (PRDX) family is a class of antioxidant enzymes with peroxidase activity.
Human PRDXs currently have six members (PRDX1–6), which are gradually becoming …

Peroxiredoxins are multifunctional enzymes that play a key role in protecting cells from
stresses and maintaining the homeostasis of many cellular processes. Peroxiredoxins were …

Significance: It has been proposed that cancer cells are heavily dependent on their
antioxidant defenses for survival and growth. Peroxiredoxins are a family of abundant thiol …

Protein S-nitrosylation, the redox-based posttranslational modification of a cysteine thiol by
the attachment of a nitric oxide (NO) group, is responsible for a variety of signaling effects …

Since the first discovery in 1961, more than 1300 ent-kaurane diterpenoids have been
isolated and identified from different plant sources, mainly the genus Isodon. Chemically …