Over the past decade, circular RNA (circRNA) research has evolved into a bona fide
research field shedding light on the functional consequence of this unique family of RNA …

Background: Acute myeloid leukemia (AML) is a biologically heterogenous disease arising
in clonally proliferating hematopoietic stem cells. Sequential acquisition of mutations leads …

Balanced rearrangements involving the KMT2A gene (KMT2A r) are recurrent genetic
abnormalities in acute myeloid leukemia (AML), but there is lack of consensus regarding the …

The interaction between menin and histone-lysine N-methyltransferase 2A (KMT2A) is a
critical dependency for KMT2A-or nucleophosmin 1 (NPM1)–altered leukemias and an …

Summary MLL/KMT2A amplifications and translocations are prevalent in infant, adult, and
therapy-induced leukemia. However, the molecular contributor (s) to these alterations are …

Dysregulated cholesterol homeostasis promotes tumorigenesis and progression. Therefore,
metabolic reprogramming constitutes a new hallmark of cancer. However, until today, only …

Aberrant expression of HOX and MEIS1 family genes, as seen in KMT2A-rearranged,
NUP98-rearranged, or NPM1-mutated leukemias leads to arrested differentiation and …

Simple Summary Owing to the 40-year worldwide efforts for improving diagnosis and
therapy for acute myeloid leukemia (AML), the second most common type of leukemia in …

Chromosomal translocations involving the mixed-lineage leukemia (MLL) locus generate
potent oncogenic fusion proteins (oncoproteins) that disrupt regulation of developmental …

MLL rearrangement (MLL r) is responsible for the development of acute leukemias with poor
outcomes. Therefore, new therapeutic approaches are urgently needed. The NOTCH1 …