Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …

Since Fleming's discovery of penicillin nearly a century ago, a bounty of natural product
antibiotics have been discovered, many of which continue to be of clinical importance today …

Bacitracin is a macrocyclic peptide antibiotic that is widely used as a topical treatment for
infections caused by gram-positive bacteria. Mechanistically, bacitracin targets bacteria by …

The title of this essay is as much a question as it is a statement. The discovery of the β-
lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if …

The peptidoglycan pathway represents one of the most successful antibacterial targets with
the last critical step being the flipping of carrier lipid, undecaprenyl phosphate (C55-P) …

Drug-resistant bacteria are a serious threat to human health as antibiotics are gradually
losing their clinical efficacy. Comprehending the mechanism of action of antimicrobials and …

Brevicidine and laterocidine are macrocyclic lipodepsipeptides with selective activity against
Gram-negative bacteria, including colistin-resistant strains. Previously, the macrocyclic core …

Covering: 1993 to the end of 2022As the rapid development of antibiotic resistance shrinks
the number of clinically available antibiotics, there is an urgent need for novel options to fill …

The study aimed to investigate the antibacterial activity, cytotoxicity, and mechanism of
action of the non-ionic, cyclic lipopeptide, serrawettin W2-FL10 against Staphylococcus …

The prevalence of drug‐resistant bacterial pathogens foreshadows a healthcare crisis.
Calcium‐dependent antibiotics (CDAs) are promising candidates to combat infectious …