Since their discovery nearly five decades ago, molecular scaffolds belonging to the 14-3-3
protein family have been recognized as pleiotropic regulators of diverse cellular and …

14–3–3 proteins play a crucial role in the regulation of protein–protein interactions,
impacting various cellular processes and disease mechanisms. Recent advancements have …

Cisplatin is a chemotherapeutic agent that is used extensively to treat solid tumors; however,
its clinical application is limited by side effects, especially nephrotoxicity. Cisplatin-induced …

Recent studies demonstrate that α cells contribute to glucose-stimulated insulin secretion
(GSIS). Glucagon-like peptide-1 receptor (GLP-1R) agonists potently potentiate GSIS …

Dysregulation of leukocyte trafficking, lipid metabolism, and other metabolic processes are
the hallmarks that underpin and drive pathology in obesity. Current clinical management …

Hyperglucagonemia has been implicated in the pathogenesis of type 2 diabetes (T2D). In
contrast to β-cells, studies on the function of the pancreatic α-cell in T2D are scarce …

Partial remission (PR) occurs in only half of people with new-onset type 1 diabetes (T1D)
and corresponds to a transient period characterized by low daily insulin needs, low glycemic …

3‐3 proteins are a ubiquitously expressed family of adaptor proteins. Despite exhibiting high
sequence homology, several 14‐3‐3 isoforms have isoform‐specific binding partners and …

The Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive
transcription factor (TF) with two major splice isoforms (α and β). In chronic hyperglycemia …

ABSTRACT Translocation of 14-3-3 protein epsilon (14-3-3ε) was found to be involved in
Triptolide (Tp)-induced inhibition of colorectal cancer (CRC) cell proliferation. However, the …