The CB 2 receptor is the peripheral receptor for cannabinoids. It is mainly expressed in
immune tissues, highlighting the possibility that the endocannabinoid system has an …

Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …

The presence and function of CB2 receptors in central nervous system (CNS) neurons are
controversial. We report the expression of CB2 receptor messenger RNA and protein …

Neurodegeneration leading to Parkinson's disease (PD) and Alzheimer's disease (AD) has
become a major health burden globally. Current treatments mainly target controlling …

In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from
eating disorders to rabies. However, as newer, more effective drugs were discovered and as …

Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids
that have been implicated in many physiologic disorders, including obesity, metabolic …

The cannabinoid system is known to be important in neuronal regulation, but is also capable
of modulating immune function. Although the CNS resident microglial cells have been …

Studies on the effects of marijuana smoking have evolved into the discovery and description
of the endocannabinoid system. To date, this system is composed of two receptors, CB1 and …

The passage of leukocytes through basement membranes involves proteolytic degradation
of extracellular matrix (ECM) components executed by focalized proteolysis. We have …

Introduction Cannabis-based medicines have a number of therapeutic indications, including
anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including …