Proteomics refers to the large-scale study of proteins, providing comprehensive and
quantitative information on proteins in tissue, blood, and cell samples. In many studies …

Nanoparticles are promising tools for nanomedicine in a wide array of therapeutic and
diagnostic applications. Yet, despite the advances in the biomedical applications of …

In eukaryotic cells, clathrin‐mediated endocytosis (CME) is a central pathway for the
internalization of proteins from the cell surface, thereby contributing to the maintenance of …

Here, we report an experimental setup to benchmark different receptors for targeted
therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial …

Targeted drug delivery requires–among others-specific interaction of nanocarriers with cell
surface receptors enabling efficient internalization into the targeted cells. Thus, identification …

Interrogation of the molecular makeup of the blood–brain barrier (BBB) using proteomic
techniques has contributed to the cataloguing and functional understanding of the proteins …

Background The active transport of molecules into the brain from blood is regulated by
receptors, transporters, and other cell surface proteins that are present on the luminal …

Current strategies to identify ligands for brain delivery select candidates based on
preferential binding to cell-membrane components (CMC) on brain endothelial cells (EC) …

Membrane proteins mediate various biological processes. Most drugs commercially
available target proteins on the cell surface. Therefore, proteomics of plasma membrane …

Abstract Background Individuals with Alzheimer's disease (AD) often require many
medications; however, these medications are dosed using regimens recommended for …