Secreted protease ADAMTS18 in development and disease

J Nie, W Zhang - Gene, 2023 - Elsevier
ADAMTS18 was identified in 2002 as a member of the ADAMTS family of 19 secreted Zinc-
dependent metalloproteinases. Prior to 2016, ADAMTS18 was known as a candidate gene …

Chemically induced colitis-associated cancer models in rodents for pharmacological modulation: A systematic review

R Modesto, J Estarreja, I Silva, J Rocha, R Pinto… - Journal of clinical …, 2022 - mdpi.com
Animal models for colitis-associated colorectal cancer (CACC) represent an important tool to
explore the mechanistic basis of cancer-related inflammation, providing important evidence …

[HTML][HTML] Chinese herbal compound SanHuang decoction reverses axitinib resistance in ccRCC through regulating immune cell infiltration by affecting ADAMTS18 …

B Xu, J Zhang, L Ye, C Yuan - American Journal of Cancer …, 2023 - ncbi.nlm.nih.gov
This investigation aims to study the reversal effect of the Chinese herbal compound
SanHuang decoction on axitinib resistance in clear cell renal cell carcinoma (ccRCC) cells …

Developmental regulation of dermal adipose tissue by BCL11b

S Traynor, S Bhattacharya, K Batmanov… - Genes & …, 2024 - genesdev.cshlp.org
The distinct anatomic environment in which adipose tissues arise during organogenesis is a
principle determinant of their adult expansion capacity. Metabolic disease results from a …

[HTML][HTML] ADAMTS12 acts as a cancer promoter in colorectal cancer via activating the Wnt/β-catenin signaling pathway in vitro

C Li, X Luo, B Huang, X Wang, Y Deng… - Annals of translational …, 2020 - ncbi.nlm.nih.gov
Background ADAMTS12, a member of the ADAMTS family, is reported to be associated with
the clinic outcome of colorectal cancer (CRC) patients. However, the functions and precise …

[HTML][HTML] ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells

L Wang, L He, W Yi, M Wang, F Xu, H Liu, J Nie… - Iscience, 2024 - cell.com
Liver sinusoidal endothelial cells (LSECs) have a unique morphological structure known as"
fenestra" that plays a crucial role in liver substance exchange and homeostasis …

Correlation between PDGF-BB and M1-type macrophage in inflammatory bowel disease: a case-control study

Z Fang, S Qu, X Ji, C Zheng, J Mo, J Xu, J Zhang… - BMC …, 2024 - Springer
Background Inflammatory bowel disease (IBD) is a chronic disease in which macrophages
play an important role in its pathogenesis. Platelet-derived growth factor-BB (PDGF-BB) …

ADAMTS18 deficiency affects neuronal morphogenesis and reduces the levels of depression-like behaviors in mice

R Zhu, YH Pan, L Sun, T Zhang, C Wang, S Ye, N Yang… - Neuroscience, 2019 - Elsevier
The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) enzymes
are secreted, multi-domain matrix-associated zinc metalloendopeptidases that modify …

Adamts18 deficiency causes spontaneous SMG fibrogenesis in adult mice

N Yang, Q Zhang, S Ye, T Lu, M Sun… - Journal of Dental …, 2022 - journals.sagepub.com
Chronic sclerosing sialadenitis of the submandibular gland (also known as Küttner tumor) is
characterized by concomitant swelling of the submandibular glands secondary to strong …

ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor

L Li, S Yuan, X Zhao, T Luo - Biochemical and Biophysical Research …, 2020 - Elsevier
Colorectal cancer (CRC) is known for being a great threat to human health due to its high
incidence and mortality. ADAMTS8 that belongs to the zinc metalloproteinases family acts as …