Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is
the fourth leading cause of cancer-related deaths in the world. Due to the broad …

Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer. PNI is a process
whereby cancer cells invade the surrounding nerves, thus providing an alternative route for …

Background Data are lacking on the efficacy and safety of a combination chemotherapy
regimen consisting of oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) as …

Accumulating lines of experimental evidence have revealed that hypoxia‐inducible factors,
HIF‐1α and HIF‐2α, are key regulators of the adaptation of cancer‐and metastasis‐initiating …

Hypoxia-inducible factor 1α (HIF1α) has emerged as a promising new target for pancreatic
cancer treatment over the past decade. High expression of HIF-1α increases the drug …

CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in
the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated …

Pancreatic cancer, one of the leading causes of cancer-related mortality, is characterized by
desmoplasia and hypovascular cancerous tissue, with a 5 year survival rate of< 8%. To …

Cancer is a heterogeneous disease manifest in many forms. Tumor histopathology can differ
significantly among patients and cellular heterogeneity within tumors is common. A primary …

Pancreatic ductal adenocarcinoma, an exocrine tumor, is the most common type of cancer of
the pancreas and one of the top five most prominent causes of cancer-associated mortality …

Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of death in cancer
and has a 5-year survival of< 5%. Only about 15% of the patients present with a resectable …