Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
SARS-CoV-2 biology and host interactions
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
Controversial properties of amyloidogenic proteins and peptides: new data in the COVID era
A Surguchov, FN Emamzadeh, M Titova, AA Surguchev - Biomedicines, 2023 - mdpi.com
For a long time, studies of amyloidogenic proteins and peptides (amyloidogenic PPs) have
been focused basically on their harmful properties and association with diseases. A vast …
been focused basically on their harmful properties and association with diseases. A vast …
COVID‐19 and the impact on Alzheimer's disease pathology
Abstract Coronavirus disease 2019 (COVID‐19) has rapidly escalated into a global
pandemic that primarily affects older and immunocompromised individuals due to …
pandemic that primarily affects older and immunocompromised individuals due to …
Viral amyloids: New opportunities for antiviral therapeutic strategies
Amyloidoses are an array of diseases associated with the aggregation of proteins into fibrils.
While it was previously thought that amyloid fibril-forming proteins are exclusively host-cell …
While it was previously thought that amyloid fibril-forming proteins are exclusively host-cell …
Bioengineered amyloid peptide for rapid screening of inhibitors against main protease of SARS-CoV-2
Abstract The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) has evoked a worldwide pandemic. As the …
syndrome coronavirus-2 (SARS-CoV-2) has evoked a worldwide pandemic. As the …
[HTML][HTML] Investigating the aggregation perspective of Dengue virus proteome
Dengue viruses are human pathogens that are transmitted through mosquitoes. Apart from
the typical symptoms associated with viral fevers, DENV infections are known to cause …
the typical symptoms associated with viral fevers, DENV infections are known to cause …
[HTML][HTML] Sex-specific biphasic alpha-synuclein response and alterations of interneurons in a COVID-19 hamster model
CS Schreiber, I Wiesweg, S Stanelle-Bertram, S Beck… - …, 2024 - thelancet.com
Summary Background Coronavirus disease 2019 (COVID-19) frequently leads to
neurological complications after recovery from acute infection, with higher prevalence in …
neurological complications after recovery from acute infection, with higher prevalence in …
[HTML][HTML] Proteomic evidence for amyloidogenic cross-seeding in fibrinaloid microclots
DB Kell, E Pretorius - International Journal of Molecular …, 2024 - pmc.ncbi.nlm.nih.gov
In classical amyloidoses, amyloid fibres form through the nucleation and accretion of protein
monomers, with protofibrils and fibrils exhibiting a cross-β motif of parallel or antiparallel β …
monomers, with protofibrils and fibrils exhibiting a cross-β motif of parallel or antiparallel β …
RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories
Many viral proteins form biomolecular condensates via liquid-liquid phase separation
(LLPS) to support viral replication and evade host antiviral responses, and thus, they are …
(LLPS) to support viral replication and evade host antiviral responses, and thus, they are …