Signal transducers and activators of transcription 5 (STAT5a and STAT5b) are highly
homologous proteins that are encoded by 2 separate genes and are activated by Janus …

Prolactin coordinates with the ovarian steroids to orchestrate mammary development and
lactation, culminating in nourishment and an increasingly appreciated array of other benefits …

The pathogenesis of cutaneous T-cell lymphoma (CTCL) remains elusive. Recent
discoveries indicate that the oncogenic microRNA miR-155 is overexpressed in affected skin …

Stat5 is constitutively activated in many human cancers affecting the expression of cell
proliferation and cell survival controlling genes. These oncogenic functions of Stat5 have …

Normal development of the mammary gland proceeds via interactions between the
epithelium and the mesenchyme that start during embryogenesis and continue during …

Human growth hormone (hGH) plays critical roles in pubertal mammary gland growth,
development, and sexual maturation. Accumulated studies have reported that …

STAT5 consists of two proteins, STAT5A/B, that impact mammary cell differentiation,
proliferation, and survival. In normal development, STAT5 expression and activity are …

A discontinuous pattern of LOH at chromosome 3p has been reported in 87% of primary
breast cancers. Despite the identification of several tumor suppressor genes in this region …

Introduction Signal transducer and activator of transcripton-5a (Stat5a) and its close
homologue, Stat5b, mediate key physiological effects of prolactin and growth hormone in …

Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related mortality with
a dismal prognosis that has changed little over the past few decades. Further understanding …