Immune checkpoint signaling and cancer immunotherapy

X He, C Xu - Cell research, 2020 - nature.com
Immune checkpoint blockade therapy has become a major weapon in fighting cancer.
Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such …

Roles of BTLA in immunity and immune disorders

Z Ning, K Liu, H Xiong - Frontiers in Immunology, 2021 - frontiersin.org
B and T lymphocyte attenuator (BTLA) is one of the most important cosignaling molecules. It
belongs to the CD28 superfamily and is similar to programmed cell death-1 (PD-1) and …

Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice

J Ramos da Silva, K Bitencourt Rodrigues… - Science Translational …, 2023 - science.org
As mRNA vaccines have proved to be very successful in battling the coronavirus disease
2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the …

Inhibitory B7-family molecules in the tumour microenvironment

W Zou, L Chen - Nature Reviews Immunology, 2008 - nature.com
The B7 family consists of activating and inhibitory co-stimulatory molecules that positively
and negatively regulate immune responses. Recent studies have shown that human and …

The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?

JS Boomer, JM Green, RS Hotchkiss - Virulence, 2014 - Taylor & Francis
Sepsis remains the leading cause of death in most intensive care units. Advances in
understanding the immune response to sepsis provide the opportunity to develop more …

B7 family checkpoint regulators in immune regulation and disease

S Ceeraz, EC Nowak, RJ Noelle - Trends in immunology, 2013 - cell.com
Fine-tuning the immune response and maintaining tolerance to self-antigens involves a
complex network of co-stimulatory and co-inhibitory molecules. The recent FDA approval of …

Checkpoint blockade in cancer immunotherapy

AJ Korman, KS Peggs, JP Allison - Advances in immunology, 2006 - Elsevier
The progression of a productive immune response requires that a number of immunological
checkpoints be passed. Passage may require the presence of excitatory costimulatory …

Herpes virus fusion and entry: a story with many characters

RJ Eisenberg, D Atanasiu, TM Cairns, JR Gallagher… - Viruses, 2012 - mdpi.com
Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ
orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often …

Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human

C Bossen, K Ingold, A Tardivel, JL Bodmer… - Journal of Biological …, 2006 - ASBMB
Ligands of the tumor necrosis factor superfamily (TNFSF)(4–1BBL, APRIL, BAFF, CD27L,
CD30L, CD40L, EDA1, EDA2, FasL, GITRL, LIGHT, lymphotoxin α, lymphotoxin αβ, OX40L …

Realigning the LIGHT signaling network to control dysregulated inflammation

CF Ware, M Croft, GA Neil - Journal of Experimental Medicine, 2022 - rupress.org
Advances in understanding the physiologic functions of the tumor necrosis factor
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …