Tissue clearing has become a powerful technique for studying anatomy and morphology at
scales ranging from entire organisms to subcellular features. With the recent proliferation of …

Over the past five years, a rapidly developing experimental approach has enabled high-
resolution and high-content information retrieval from intact multicellular animal (metazoan) …

Breast tumors are inherently heterogeneous, but the evolving cellular organization through
neoplastic progression is poorly understood. Here we report a rapid, large-scale single-cell …

CLARITY is a tissue clearing method, which enables immunostaining and imaging of large
volumes for 3D-reconstruction. The method was initially time-consuming, expensive and …

Tissue optical clearing techniques provide alternative approaches for imaging large-volume
specimens. uDISCO, an organic-solvent-based method, stands out from the enormous array …

Cerebral (or brain) organoids derived from human cells have enormous potential as
physiologically relevant downscaled in vitro models of the human brain. In fact, these stem …

The development of robust tools for segmenting cellular and sub-cellular neuronal structures
lags behind the massive production of high-resolution 3D images of neurons in brain tissue …

CLARITY is a novel tissue clearing technique that transforms intact biological tissues into a
nanoporous hydrogel‑tissue hybrid, preserving anatomical structures, proteins and nucleic …

Background Post mortem human brain tissue is an essential resource to study cell types,
connectivity as well as subcellular structures down to the molecular setup of the central …

Cryo-imaging sections and images a whole mouse and provides~ 120-GBytes of
microscopic 3D color anatomy and fluorescence images, making fully manual analysis of …