Heat shock protein (HSP) synthesis is switched on in a remarkably wide range of tumor
cells, in both experimental animal systems and in human cancer, in which these proteins …

Collagen is the dominant protein of the extracellular matrix. Its distinguishing feature is a
three-stranded helix of great tensile strength.(2 S, 4 R)-4-Hydroxyproline residues are …

Bioprinting of cellular aggregates, such as tissue spheroids, to form three-dimensional (3D)
complex-shaped arrangements, has posed a major challenge due to lack of robust …

Idiopathic Pulmonary fibrosis (IPF) is a catastrophic disease with poor outcomes and limited
pharmacological approaches. Heat shock protein 90 (HSP90) has been recently involved in …

The extracellular matrix (ECM) is a dynamic and organised extracellular network assembled
from proteins and carbohydrates exported from the cell. The ECM is critical for multicellular …

Protein folding in the cell is mediated by an extensive network of> 1,000 chaperones, quality
control factors, and trafficking mechanisms collectively termed the proteostasis network …

Secretion and quality control of large extracellular matrix proteins remain poorly understood
and debated, particularly transport intermediates delivering folded proteins from the ER to …

The collagenopathies are a diverse group of diseases caused primarily by mutations in
collagen genes. The resulting disruptions in collagen biogenesis can impair development …

Exposure to high concentrations of hydrochloric acid (HCl) can lead to severe acute and
chronic lung injury. In the aftermath of accidental spills, victims may be treated for the acute …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that is often fatal
due to the formation of irreversible scar tissue in the distal areas of the lung. Although the …