The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …

The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in
patients with Alzheimer's disease. We applied focused ultrasound with each of six monthly …

Intracerebral vector delivery in nonhuman primates has been a major challenge. We report
successful blood-brain barrier opening and focal delivery of adeno-associated virus …

Background Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has
shown efficacy in removal of amyloid plaque and improvement of cognitive functions in …

Background Parkinson's disease (PD) exhibits a high prevalence of dementia as disease
severity and duration progress. Focused ultrasound (FUS) has been applied for transient …

The blood–brain barrier (BBB) protects the brain but is also an important obstacle for the
effective delivery of therapeutics in Alzheimer's disease and other neurodegenerative …

OBJECTIVE MRI-guided low-intensity focused ultrasound (FUS) has been shown to
reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic agents …

An emerging approach with potential in improving the treatment of neurodegenerative
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …

Background Aducanumab is an anti-amyloid-β (Aβ) antibody that achieved reduced amyloid
pathology in Alzheimer's disease (AD) trials; however, it is controversial whether it also …