The respiratory system acts as both the primary site of gas exchange and an important
sensor and barrier to the external environment. The increase in incidences of respiratory …

Lung inflammatory disorders are a major global health burden, impacting millions of people
and raising rates of morbidity and death across many demographic groups. An industrial …

In vivo genome correction holds promise for generating durable disease cures; yet, effective
stem cell editing remains challenging. In this work, we demonstrate that optimized lung …

The airway surface liquid (ASL) plays a crucial role in lung defense mechanisms, and its
composition and volume are regulated by the airway epithelium. The cystic fibrosis …

Cystic fibrosis (CF) is a fatal autosomal recessive disorder caused by the loss of function
mutations within a single gene for the Cystic Fibrosis Transmembrane Conductance …

Base editing could correct nonsense mutations that cause cystic fibrosis (CF), but clinical
development is limited by the lack of delivery methods that efficiently breach the barriers …

The dosing interval for effective recombinant adeno-associated virus (rAAV)-mediated gene
therapy of cystic fibrosis lung disease remains unknown. Here, we assessed the durability of …

The epithelial lining of the respiratory tract and intestine provides a critical physical barrier to
protect host tissues against environmental insults including dietary antigens, allergens …

The lungs serve as the primary organ for respiration, facilitating the vital exchange of gases
with the bloodstream. Given their perpetual exposure to external particulates and …

Background Pulmonary ionocytes have been identified in the airway epithelium as a small
population of ion transporting cells expressing high levels of CFTR (cystic fibrosis …