Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …

Background Deposition of amyloid β, which is produced by amyloidogenic cleavage of APP
by β-and γ-secretase, is one of the primary hallmarks of AD pathology. APP can also be …

Neural mechanisms underlying amputation-related secondary pain are unclear. Using in
vivo two-photon imaging, three-dimensional reconstruction, and fiber photometry recording …

Inflammatory–oxidative stress is known to be pivotal in the pathobiology of Alzheimer's
disease (AD), but the involvement of this stress at the peripheral level in the disease's onset …

The identification of neuroinflammation as a critical factor in Alzheimer's disease (AD) has
expanded the focus of research beyond amyloid-β and tau pathology. The …

Abstract Alzheimer's disease (AD), as a neurodegenerative disorder, distresses the elderly
in large numbers and is characterized by β-amyloid (Aβ) accumulation, elevated tau protein …

In this issue of Neuron, Essayan-Perez and Südhof 1 demonstrate roles for γ-secretase in
the regulation of synaptic functions in human neurons. Chronic attenuation of γ-secretase …

Alzheimer's disease (AD) is an age‐related neurodegenerative disease with amyloid‐β (Aβ)
deposition as the main pathological feature. It's an important challenge to find new ways to …

Generative pretrained models represent a significant advancement in natural language
processing and computer vision, which can generate coherent and contextually relevant …