Epigenetic regulation is critical to physiological control of development, cell fate, cell
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …

Chondrosarcoma is the second most common primary bone tumor, with> 90% of cases
representing the primary conventional subtype. In addition to arising de novo, conventional …

Simple Summary Chondrosarcoma (CHS) belongs to a broad group of sarcomas and is the
second most frequent malignant bone tumor. Due to its resistance to chemo-and …

Simple Summary This review article aims in describing the origins of chondrosarcoma
radiation-resistance and proposes several potential solutions in order to improve the …

Simple Summary Chondrosarcomas are cartilage tumours that often harbour a mutation in
one of the isocitrate dehydrogenase (IDH) genes. IDH mutations are important drivers at the …

Introduction IDH1/2 mutations are prevalent in cartilaginous tumors including
chondrosarcoma. This meta‐analysis using individual patient data (IPD) aimed to …

Background. Recent studies have shown that isocitrate dehydrogenase 1/2 (IDH1/2)-
activating mutations occur in a variety of cancers, including acute myeloid leukaemia …

Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of
isocitrate to α-ketoglutarate (α-KG). Mutations in IDH lead to loss of normal enzymatic activity …

Chondrosarcomas are the most common malignant tumors of the cartilage, are seen
predominantly in adults, and have varied clinical behavior. The majority of them affect the …

Dedifferentiated chondrosarcoma is a rare bone sarcoma, whose genetic background
remains incompletely understood. Mutations in SUZ12 or EED, which encode polycomb …