Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and
disability in infants and children. Although several preclinical models using rodents of …

Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Preterm birth is an evolving challenge in neonatal health care. Despite declining mortality
rates among extremely premature neonates, morbidity rates remain very high. Currently …

Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity
worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on …

Myelination in the central nervous system is the process by which oligodendrocytes form
myelin sheaths around the axons of neurons. Myelination enables neurons to transmit …

The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been
implicated in regulating neural differentiation, survival, proliferation, migration, and cell …

Cerebral white matter injury (WMI) persistently disrupts myelin regeneration by
oligodendrocyte progenitor cells (OPCs). We identified a specific bioactive hyaluronan …

Approximately one quarter of all strokes in humans occur in white matter, and the
progressive nature of white matter lesions often results in severe physical and mental …

Fetal growth restriction (FGR) is a common complication of pregnancy, principally caused by
suboptimal placental function, and is associated with high rates of perinatal mortality and …

Epidemiological and experimental data implicate maternal infection and inflammation in the
etiology of brain white matter injury, which may lead to cerebral palsy in preterm newborns …