That cancer cells show patterns of metabolism different from normal cells has been known
for over 50 years. Yet, it is only in the past decade or so that an appreciation of the benefits …

A paradox for the cancer biology field has been the revelation that oncogenes, once thought
to simply provide advantages to a cancer cell, actually put it at dire risk of cell suicide. Myc is …

The transcription factor Myc is induced by mitogenic signals and regulates downstream
cellular responses. If overexpressed, Myc promotes malignant transformation. Myc …

Advanced human cancers are invariably aneuploid, in that they harbour cells with abnormal
chromosome numbers,. However, the molecular defects underlying this trait, and whether …

Disruption of the physiologic balance between cell proliferation and death is a universal
feature of all cancers. In general terms, human B-cell lymphomas can be subdivided into 2 …

Tumor cells have a dysregulated cell cycle that may render their proliferation especially
sensitive to the inhibition of cyclin-dependent kinases (CDKs), important regulators of cell …

To identify target genes of the oncogenic transcription factor c-MYC, serial analysis of gene
expression (SAGE) was performed after adenoviral expression of c-MYC in primary human …

Cerebellar granule cells are the most abundant neurons in the brain, and granule cell
precursors (GCPs) are a common target of transformation in the pediatric brain tumor …

The primary aim of this study was to evaluate the antitumor efficacy of the bromodomain
inhibitor JQ1 in pancreatic ductal adenocarcinoma (PDAC) patient-derived xenograft …

Deregulation in different steps of translational control is an emerging mechanism for cancer
formation. One example of an oncogene with a direct role in control of translation is the Myc …