Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a
severe type of stroke which is, in part, driven by genetic variation. In the past 10 years …

Spontaneous subarachnoid hemorrhage (SAH) affects people with a mean age of 55 years.
Although there are about 9/100 000 cases per year worldwide, the young age and high …

Background: Recently, common genetic risk factors for intracranial aneurysm (IA) and
aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of …

Cerebrovascular diseases that cause ischaemic or haemorrhagic stroke with subsequent
loss of life or functional capacity due to damage of the brain tissue are among the leading …

The chapter describes the epidemiology of cerebrovascular diseases, anatomy of the
cerebral blood vessels, pathophysiology of ischemia, hypoxia, hypoxemia, anemic hypoxia …

BACKGROUND It is assumed that high pore densities in flow diverters (FDs) are beneficial
for intracranial aneurysm (IA) healing. However, various animal studies are not conclusive …

Introduction: A higher prevalence of intracranial aneurysms (IAs) has been previously
reported by retrospective studies in patients with thoracic aortic aneurysms (TAAs). The goal …

Since the completion of the first genome-wide asso-ciation studies in the early 2000s,
polygenic risk prediction has raised considerable expectations for research and clinical use …

Background Rupture of an intracranial aneurysm (IA) causes aneurysmal subarachnoid
hemorrhage (ASAH). There is no accurate prediction model for IA or ASAH in the general …

Medicine, Yang et al20 demonstrated that a rare and low-frequency variant (rs2298808) of
ARHGEF17 is significantly associated with IAs. The study design has used sophisticated …