Effect of the Rho-kinase/ROCK signaling pathway on cytoskeleton components

G Guan, RD Cannon, DE Coates, L Mei - Genes, 2023 - mdpi.com
The mechanical properties of cells are important in tissue homeostasis and enable cell
growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties …

Coherent light scattering from cellular dynamics in living tissues

DD Nolte - Reports on Progress in Physics, 2024 - iopscience.iop.org
This review examines the biological physics of intracellular transport probed by the coherent
optics of dynamic light scattering from optically thick living tissues. Cells and their …

Microtubule detyrosination drives symmetry breaking to polarize cells for directed cell migration

K Lavrsen, G Rajendraprasad… - Proceedings of the …, 2023 - National Acad Sciences
To initiate directed movement, cells must become polarized, establishing a protrusive
leading edge and a contractile trailing edge. This symmetry-breaking process involves …

Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography

I Abd El-Sadek, LTW Shen, T Mori, S Makita… - Scientific Reports, 2023 - nature.com
This study aims at demonstrating label-free drug-response-patterns assessment of different
tumor spheroids and drug types by dynamic optical coherence tomography (D-OCT). The …

Modulation of microtubule properties and functions by encapsulation of nanomaterials using a Tau-derived peptide

H Inaba, K Matsuura - Bulletin of the Chemical Society of Japan, 2021 - academic.oup.com
Microtubules (MTs) are hollow cytoskeletons with typically 15 nm inner diameter, which are
crucial for various cellular activities including structural support, transport, and cell division …

[HTML][HTML] The centriolar tubulin code

P Guichard, MH Laporte, V Hamel - Seminars in cell & developmental …, 2023 - Elsevier
Centrioles are microtubule-based cell organelles present in most eukaryotes. They
participate in the control of cell division as part of the centrosome, the major microtubule …

Synergistic stabilization of microtubules by BUB-1, HCP-1, and CLS-2 controls microtubule pausing and meiotic spindle assembly

N Macaisne, L Bellutti, K Laband, F Edwards… - Elife, 2023 - elifesciences.org
During cell division, chromosome segregation is orchestrated by a microtubule-based
spindle. Interaction between spindle microtubules and kinetochores is central to the bi …

[HTML][HTML] Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration

J Li, C Fan, Z Lv, Z Sun, J Han, M Wang, H Jiang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Purpose: Chondrocytes (CHs) in cartilage undergo several detrimental events during the
development of osteoarthritis (OA). However, the mechanism underlying CHs regeneration …

Septum-associated microtubule organizing centers within conidia support infectious development by the blast fungus Magnaporthe oryzae

AM Rogers, MJ Egan - Fungal Genetics and Biology, 2023 - Elsevier
Cytoplasmic microtubule arrays play important and diverse roles within fungal cells,
including serving as molecular highways for motor-driven organelle motility. While the …

Nucleus-cytoskeleton communication impacts on OCT4-chromatin interactions in embryonic stem cells

JJ Romero, MC De Rossi, C Oses, CV Echegaray… - BMC biology, 2022 - Springer
Background The cytoskeleton is a key component of the system responsible for transmitting
mechanical cues from the cellular environment to the nucleus, where they trigger …