Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy
Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …
types. With the multifactorial nature of cancer, and the fast development of drug resistance …
Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances
P Dhokne, AP Sakla, N Shankaraiah - European journal of medicinal …, 2021 - Elsevier
Small-molecule kinase inhibitors are being continuously explored as new anticancer
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
New quinoxaline-2 (1 H)-ones as potential VEGFR-2 inhibitors: Design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations
Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2
inhibitors of our previous work. The synthesized compounds were tested against three …
inhibitors of our previous work. The synthesized compounds were tested against three …
Discovery of new quinoxaline-2 (1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation
VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis, biological …
SM Al-Muntaser, AA Al-Karmalawy, AM El-Naggar… - RSC …, 2023 - pubs.rsc.org
In this article, we continued our previous effort to develop new selective anticancer
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …
Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: Virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular …
RG Yousef, A Ibrahim, MM Khalifa… - Journal of enzyme …, 2022 - Taylor & Francis
A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual
screening was conducted for the hypothetical library using in silico docking, ADMET, and …
screening was conducted for the hypothetical library using in silico docking, ADMET, and …
Development of isatin-thiazolo [3, 2-a] benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and …
In the current medical era, human health is experiencing numerous challenges, particularly
the human malignancies. Therefore, the therapeutic arsenal for these malignancies is to be …
the human malignancies. Therefore, the therapeutic arsenal for these malignancies is to be …
Discovery of new quinolines as potent colchicine binding site inhibitors: Design, synthesis, docking studies, and anti-proliferative evaluation
M Hagras, MA El Deeb, HSA Elzahabi… - Journal of Enzyme …, 2021 - Taylor & Francis
Discovering of new anticancer agents with potential activity against tubulin polymerisation is
still a promising approach. Colchicine binding site inhibitors are the most relevant anti …
still a promising approach. Colchicine binding site inhibitors are the most relevant anti …
Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors …
AM Saleh, HA Mahdy, MA El-Zahabi, ABM Mehany… - RSC …, 2023 - pubs.rsc.org
A novel series of pyrimidine-5-carbonitrile derivatives bearing benzylidene and hydrazone
moieties with different linkers (spacers) were designed and synthesized as possible …
moieties with different linkers (spacers) were designed and synthesized as possible …
Recent development in indole derivatives as anticancer agent: A mechanistic approach
N Devi, K Kaur, A Biharee… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …