Diabetes and its complications cause a heavy disease burden globally. Identifying
exposures, risk factors and molecular processes causally associated with the development …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Background To explore the associations of genetically proxied TYK2 inhibition with a wide
range of disease outcomes and biomarkers to identify therapeutic repurposing opportunities …

We conduct proteome-wide Mendelian randomization and colocalization analyses to
decipher the associations of blood proteins with the risk of type 2 diabetes and diabetic …

Abstract Background Lipoprotein (a)[Lp (a)] is a risk factor for atherosclerotic and valvular
diseases, but its possible role in other diseases has not yet been established. We conducted …

Background Sex hormones and sex hormone-binding globulin (SHBG) may play a role in
fatty liver development. We sought to examine the association of various endogenous sex …

OBJECTIVE The plasma proteome preceding diabetes can improve our understanding of
diabetes pathogenesis. RESEARCH DESIGN AND METHODS In 8,923 Atherosclerosis Risk …

X-chromosomal genetic variants are understudied but can yield valuable insights into
sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry …

Exogenous and endogenous exposure to aldehydes is seen worldwide. Aldehydes are
closely associated with human diseases, especially reproductive toxicity. However, the effect …

Hypertension (HT) is a modifiable risk factor for life-threatening cardiovascular diseases
(CVDs) including coronary artery disease, heart failure, or stroke. Despite significant …