[HTML][HTML] Role and therapeutic targeting of the PI3K/Akt/mTOR signaling pathway in skin cancer: a review of current status and future trends on natural and synthetic …

JC Chamcheu, T Roy, MB Uddin, S Banang-Mbeumi… - Cells, 2019 - mdpi.com
The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-
inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation …

Development of Personalized Strategies for Precisely Battling Malignant Melanoma

AJ Isaak, GGR Clements, RGM Buenaventura… - International Journal of …, 2024 - mdpi.com
Simple Summary Precision oncology is emerging as a viable option to improve survival in
patients who fail to remain disease-free even after the employment of currently available …

The positive correlation between drug addiction and drug dosage in vemurafenib-resistant melanoma cells is underpinned by activation of ERK1/2-FRA-1 pathway

M Rao, B Shi, Y Yuan, Y Wang, Y Chen, X Liu… - Anti-Cancer …, 2020 - journals.lww.com
Malignant melanoma is a kind of highly invasive and deadly diseases. The BRAF inhibitor
(BRAFi) such as vemurafenib could achieve a high response rate in melanoma patients with …

Role Of Pi3k/Akt/Mtor Pathways Behind Pathogenesis Of Skin Cancer: A Brief Review

S Rakshit, V Chitra - NeuroQuantology, 2022 - search.proquest.com
Skin cancer contributes to all most 30% of all newly diagnosed cancers in the world. Majorly
two risk factors contribute to the pathophysiology of many skins carcinogenesis, which …

Evaluation of the effect of a nitric oxide synthase inhibitor (L-NAME) and nitrogen radical donor (NPS) on the cytotoxicity, genotoxicity and clonogenic potential of …

L Bonfim - inis.iaea.org
Melanoma is classically described as one of the tumors that has high radioresistance in both
in vitro and clinical studies. Nitric oxide is a molecule that performs various functions in the …

Oncogenic signalling in BRAF/RAS wild type melanoma

M Zizhen - 2022 - figshare.mq.edu.au
Selective inhibition of the mitogen-activated protein kinase (MAPK) pathway has significantly
improved the survival of patients with BRAF V600-mutant advanced melanoma. However …

Avaliação do efeito de um inibidor da óxido nítrico sintase (L-NAME) e de um doador de radicais de nitrogênio (NPS) na citotoxicidade, genotoxicidade e potencial …

L Bonfim - teses.usp.br
O melanoma é classicamente descrito como um dos tumores que possuem alta
radioresistência, tanto em experimentos in vitro quanto em estudos clínicos. O óxido nítrico …