Transitioning metal–organic frameworks from the laboratory to market through applied research
Metal–organic frameworks (MOFs) have captivated researchers for over 25 years, yet few
have successfully transitioned to commercial markets. This Perspective elucidates the …
have successfully transitioned to commercial markets. This Perspective elucidates the …
Applications of artificial intelligence and machine learning algorithms to crystallization
Artificial intelligence and specifically machine learning applications are nowadays used in a
variety of scientific applications and cutting-edge technologies, where they have a …
variety of scientific applications and cutting-edge technologies, where they have a …
Continuous crystallization processes in pharmaceutical manufacturing: A review
J Orehek, D Teslic, B Likozar - Organic Process Research & …, 2020 - ACS Publications
This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …
Experimental investigation of an integrated crystallization and wet-milling system with temperature cycling to control the size and aspect ratio of needle-shaped …
A Eren, B Szilagyi, JL Quon… - Crystal Growth & …, 2021 - ACS Publications
Control of crystal size distribution (CSD) and shape is critical in the pharmaceutical
industries for meeting tight critical quality attribute (CQA) requirements in the manufacturing …
industries for meeting tight critical quality attribute (CQA) requirements in the manufacturing …
Modeling of pharmaceutical filtration and continuous integrated crystallization-filtration processes
As continuous manufacturing is evolving in the pharmaceutical industry, continuous filtration
has emerged as a bottleneck for connecting the crystallization of the active pharmaceutical …
has emerged as a bottleneck for connecting the crystallization of the active pharmaceutical …
Integrated Continuous Crystallization–-Spherical Agglomeration (CCSA) Process for the Intensified Manufacturing of Atorvastatin Calcium
This study applies an innovative two-stage continuous manufacturing process for
atorvastatin calcium (ASC), focusing on the integration of process intensification through …
atorvastatin calcium (ASC), focusing on the integration of process intensification through …
Process-induced crystal surface anisotropy and the impact on the powder properties of odanacatib
Crystalline active pharmaceutical ingredients with comparable size and surface area can
demonstrate surface anisotropy induced during crystallization or downstream unit …
demonstrate surface anisotropy induced during crystallization or downstream unit …
A mechanistic model to predict droplet drying history and particle shell formation in multicomponent systems
Spray drying allows tuning the physical properties of the resulting powders widely. However,
targeted process design is complicated by the interplay between process characteristics and …
targeted process design is complicated by the interplay between process characteristics and …
Process analytical technology in Downstream-Processing of Drug Substances–A review
P Neugebauer, M Zettl, D Moser, J Poms… - International Journal of …, 2024 - Elsevier
Abstract Process Analytical Technology (PAT) has revolutionized pharmaceutical
manufacturing by providing real-time monitoring and control capabilities throughout the …
manufacturing by providing real-time monitoring and control capabilities throughout the …
Process Performance and Operational Challenges in Continuous Crystallization: A Study of the Polymorphs of L-Glutamic Acid
The crystallization of the two polymorphs of l-glutamic acid (LGA) is carried out in a
continuous crystallization process, and its performance according to different criteria is …
continuous crystallization process, and its performance according to different criteria is …