Rheumatoid arthritis (RA) is a common, chronic, systemic autoimmune disease, and its
clinical features are the proliferation of joint synovial tissue, the formation of pannus and the …

Rheumatoid arthritis (RA) is a chronic, systemic immune-mediated inflammatory disease that
can lead to joint destruction, functional disability and substantial comorbidity due to the …

Neutrophils release extracellular traps (NETs) in response to numerous pathogenic
microbes as the last suicidal resource (NETosis) in the fight against infection. Apart from the …

Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is
classed into three subfamilies based on their structural and activation characteristics …

ABSTRACT Introduction The Janus kinase family includes four members–JAK1, JAK2,
JAK3, TYK2-that are selectively associated with type I and II cytokine receptors. Jak …

Rheumatoid arthritis (RA) is a highly prevalent autoimmune disorder. The pathogenesis of
the disease is complex and involves various cellular populations, including fibroblast-like …

Purpose Tofacitinib, a janus kinase (JAK) inhibitor, was developed for the treatment of
rheumatoid arthritis. To evaluate its pharmacokinetic characteristics, a simple method of …

Background. It is commonly believed that mTOR inhibitors (mTORi) should not be used in
high-immunological risk kidney transplant recipients due to a perceived increased risk of …

In this Research Topic of Frontiers in Medicine, our aim was to highlight advances in B-cell
therapies in various rheumatic and musculoskeletal diseases (RMD) to further refine their …

РЕЗЮМЕ Цель исследования: провести непрямой сравнительный анализ динамики
клинико-лабораторных показателей воспалительной активности заболевания у …