Understanding the growth hormone therapy adherence paradigm: a systematic review

BG Fisher, CL Acerini - Hormone Research in Paediatrics, 2013 - karger.com
Introduction: Growth hormone (GH) therapy is used to treat a variety of growth disorders in
childhood/adolescence. Its efficacy is thought to be dependent on patients' adherence to …

The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults

LJ Woodhouse, A Mukherjee, SM Shalet… - Endocrine …, 2006 - academic.oup.com
The availability of recombinant human GH and somatostatin analogs has resulted in
widespread treatment for adults with GH deficiency (GHD) and those with GH excess …

Hypopituitarism following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a preliminary report

DF Kelly, ITG Gonzalo, P Cohan, N Berman… - Journal of …, 2000 - thejns.org
Object. Recognition of pituitary hormonal insufficiencies after head injury and aneurysmal
subarachnoid hemorrhage (SAH) may be important, especially given that hypopituitarism …

Growth hormone (GH) replacement therapy in adult-onset GH deficiency: effects on body composition in men and women in a double-blind, randomized, placebo …

AR Hoffman, JE Kuntze, J Baptista… - The Journal of …, 2004 - academic.oup.com
Adult GH deficiency (AGHD) is characterized by an altered body composition, an
atherogenic lipid profile, decreased exercise capacity, and diminished quality of life. We …

IGFs and IGFBPs: role in health and disease

R Monzavi, P Cohen - Best Practice & Research Clinical Endocrinology & …, 2002 - Elsevier
The insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases
are the main regulators of somatic growth and cellular proliferation. IGFs are involved in …

Optimizing GH therapy in adults and children

WM Drake, SJ Howell, JP Monson… - Endocrine …, 2001 - academic.oup.com
Until the advent of modern neuroradiological imaging techniques in 1989, a diagnosis of GH
deficiency in adults carried little significance other than as a marker of hypothalamo-pituitary …

Quality of life (QOL) in patients with acromegaly is severely impaired: use of a novel measure of QOL: acromegaly quality of life questionnaire

SV Rowles, L Prieto, X Badia, SM Shalet… - The Journal of …, 2005 - academic.oup.com
Acromegaly Quality of Life Questionnaire (AcroQoL) is a new disease-generated quality of
life (QOL) questionnaire comprising 22 questions covering physical and psychological …

Observations of nonadherence to recombinant human growth hormone therapy in clinical practice

F Haverkamp, L Johansson, H Dumas, S Langham… - Clinical Therapeutics, 2008 - Elsevier
Background: The effectiveness of all prescribed treatments is contingent on patient
adherence. The reported levels of adherence to recombinant human growth hormone (r …

Therapy in endocrine disease: body composition and quality of life in adults treated with GH therapy: a systematic review and meta-analysis

A Hazem, MB Elamin, I Bancos… - European journal of …, 2012 - academic.oup.com
Objective To summarise the evidence about the efficacy and safety of using GH in adults
with GH deficiency focusing on quality of life and body composition. Data sources We …

Long-term improvement of quality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction …

M Rosilio, WF Blum, DJ Edwards… - The Journal of …, 2004 - academic.oup.com
Abstract Questions on Life Satisfaction-Hypopituitarism (QLS-H) is a new quality-of-life (QoL)
questionnaire developed for adults with hypopituitarism. To determine the effects of long …