Since the first success of interleukin-1 blockade in cryopyrin-associated periodic syndrome,
the use of interleukin-1 inhibitors has expanded to other disorders, including off-label …

The innate immune system is a hushed stronghold that protects living beings from microbial
pathogens, damaged tissue, biochemical stress, dysmetabolism, or dysbiosis by means of …

Patient registries are a very important and essential tool for investigating rare diseases, as
most physicians only see a limited number of cases during their career. Diseases of multi …

Objective Inflammation has been associated with an increased risk for cancer development,
while innate immune system activation could counteract the risk for malignancies. Familial …

Abstract Background Systemic autoinflammatory diseases (SAIDs) are a group of disorders
related to defective regulation of the innate immune system. Recurrence of inflammation can …

Introduction This study aims to explore awareness, knowledge, and diagnostic/therapeutic
practices in monogenic uveitis (mU) among uveitis experts. Methods This is an explorative …

Objective Colchicine is the mainstay of familial Mediterranean fever treatment and
interleukin (IL-1) antagonists are the treatment of choice in resistant patients. We aimed to …

The impact of the COVID-19 pandemic on new diagnoses of recurrent fevers and
autoinflammatory diseases is largely unknown. The Childhood Arthritis and Rheumatology …

Background Nearly 50 pathogenic genes and hundreds of pathogenic variants have been
identified in monogenic autoinflammatory diseases (AIDs). Nonetheless, there are still many …

VEXAS syndrome, is a hemato-inflammatory chronic disease characterized with
predominantly rheumatic and hematologic systemic involvement. It was first described in …