Natural products have been proven as the main source of biologically active compounds,
which are potentially useful for drug development. As one of the most studied pentacyclic …

This study investigated the antioxidant activity DPPH, ABTS, and Folin–Ciocalteu methods of
betulin (compound 1) and its derivatives (compounds 2–11). Skin permeability and …

The natural compound betulin has been extensively explored for its potential application as
an anticancer agent in recent years. Presently, the betulin compound was isolated from the …

The frequency of human being suffering from cancer is increasing annually throughout the
world, but treatment of cancer is becoming more complex in recent years due to the …

A series of 30-diethylphosphate derivatives of betulin were synthesized and evaluated for
their in vitro cytotoxic activity against human cancer cell lines, such as amelanotic melanoma …

Betulin and its derivatives, 28-propyne derivative EB5 and 29-diethyl phosphonate analog
ECH147, are promising compounds in anti-tumor activity studies. However, their effect on …

α, β-Unsaturated lupane and 19β, 28-epoxy-18α-oleanane aldehydes were used in the
synthesis of triterpenoids bearing substituted 1, 2-azole moieties (1-acetyl-3-methyl-4, 5 …

Three groups of bile acid derivatives with acetylenic moieties, such as propargyl, hex-5-
ynoyl, and 4, 7, 10, 13-tetraoxahexadec-15-ynoyl ones, were obtained. The cytotoxic activity …

New ligands for targeted delivery to the liver based on glycoconjugated natural triterpenoids
are proposed. Simple chemical transformations of starting lupane triterpenes led to betulin …

A new promising conjugate of betulinic acid with N-acetyl-d-galactosamine was synthesized
by the simple reaction sequence: esterification and copper-catalyzed azide-alkyne …