Inflammation and post‐traumatic stress disorder

H Hori, Y Kim - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
While post‐traumatic stress disorder (PTSD) is currently diagnosed based solely on classic
psychological and behavioral symptoms, a growing body of evidence has highlighted a link …

Inflammation in fear-and anxiety-based disorders: PTSD, GAD, and beyond

V Michopoulos, A Powers, CF Gillespie… - …, 2017 - nature.com
The study of inflammation in fear-and anxiety-based disorders has gained interest as
growing literature indicates that pro-inflammatory markers can directly modulate affective …

Holocaust exposure induced intergenerational effects on FKBP5 methylation

R Yehuda, NP Daskalakis, LM Bierer, HN Bader… - Biological …, 2016 - Elsevier
Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …

Stress, glucocorticoids and memory: implications for treating fear-related disorders

D de Quervain, L Schwabe… - Nature Reviews …, 2017 - nature.com
Glucocorticoid stress hormones are crucially involved in modulating mnemonic processing
of emotionally arousing experiences. They enhance the consolidation of new memories …

The genetics of stress-related disorders: PTSD, depression, and anxiety disorders

JW Smoller - Neuropsychopharmacology, 2016 - nature.com
Research into the causes of psychopathology has largely focused on two broad etiologic
factors: genetic vulnerability and environmental stressors. An important role for …

Biological studies of post-traumatic stress disorder

RK Pitman, AM Rasmusson, KC Koenen… - nature Reviews …, 2012 - nature.com
Post-traumatic stress disorder (PTSD) is the only major mental disorder for which a cause is
considered to be known: that is, an event that involves threat to the physical integrity of …

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

T Klengel, D Mehta, C Anacker, M Rex-Haffner… - Nature …, 2013 - nature.com
Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …

Animal models of PTSD: a challenge to be met

G Richter-Levin, O Stork, MV Schmidt - Molecular psychiatry, 2019 - nature.com
Recent years have seen increased interest in psychopathologies related to trauma
exposure. Specifically, there has been a growing awareness to posttraumatic stress disorder …

Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder

D Mehta, T Klengel, KN Conneely… - Proceedings of the …, 2013 - National Acad Sciences
Childhood maltreatment is likely to influence fundamental biological processes and engrave
long-lasting epigenetic marks, leading to adverse health outcomes in adulthood. We aimed …

Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder

AL Mahan, KJ Ressler - Trends in neurosciences, 2012 - cell.com
Posttraumatic stress disorder (PTSD) is an anxiety disorder that can develop after a
traumatic experience such as domestic violence, natural disasters or combat-related trauma …